The present study evaluated opportunistic body composition in healthy Korean adults who performed FDG-PET/CT for cancer screening. FDG-PET/CT, dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), clinical history, and laboratory data of healthy Korean adults (M:F= 136:131, 60.76 ± 9.95y) who performed health screening program at our institute from 2017 to 2022 were analyzed. The distribution and quantification of abdominal visceral (VAT) and subcutaneous (SAT) fat tissues, crossed skeletal muscle area (CSMA) were evaluated, and bone mineral density (BMD), fat contents of liver and muscle were measured as Hounsfield unit (HU) level using non-enhanced CT images of FDG-PET/CT. Metabolic activity of all these tissues was measured on PET images of FDG-PET/CT. BMD and HU of the muscle steadily decreased with age. Both CSMA and BMD decreased with age, and they well correlated each other. CSMA was inversely correlated with the amount of SAT and VAT. Not SAT but VAT significantly increased with age. Fat content of liver was correlated with age and inversely correlated with CSMA only in women. In comparisons of normal and fatty liver groups, HU of the muscle was significant lower in the fatty liver group, but metabolism of the muscle was not different. Amount of both SAT and VAT were significantly larger, while glucose metabolism of both SAT and VAT were lower in the fatty liver group than in the normal group. Sarcopenic individuals tend to be osteopenic and obese, and present more fatty content in the liver and muscle.

Authors:
So Won Oh, Seoul National University Boramae Medical Center, South Korea
Chang-Myung Oh, Gwangju Institute of Science and Technology, South Korea
Yong Hwy Kim, Seoul National University, South Korea
Jae Kyung Lee, Seoul National University Boramae Medical Center, South Korea
Jee Won Chai, Seoul National University Boramae Medical Center, South Korea

About the Presenter(s)
Dr So Won Oh is a University Associate Professor/Senior Lecturer at Seoul National University Boramae Medical Center in South Korea

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